Experimental evaluation on analgesic activity of Erandamoola (Ricinus communis) collected in three different seasons wsr to Dravya Samgrahana Kaala

Abstract

About: Dravya samgrahana kaala is an important scientific documentation mentioned in Ayurveda where there will be change in activity and phytochemical profile of plants in different seasons. Erandamoola (Ricinus communis) is an important medicinal plant where roots are particularly indicated as analgesic. As per Dravya samgrahana vidhi roots are to be collected in Hemanth-Shishira or Greeshma rutu or Pravarat rutu. Hence with this background study has been planned to evaluate analgesic activity of the Erandamoola (Ricinus cumunis) collected in Greeshma (EMG) and Pravrutritu (EMP) and Shishiraritu (EMS) using Eddy’s Hot plate method, in swiss albino mice. Materials and Methods: Roots of matured plant will be collected in three different seasons, shade dried, powdered and used for the study. Swiss Albino mice were randomly grouped into 3 groups of six animals each. Group I served as control, Group II serve as standard with administration of Tramadol whereas Group III (EMG), Group IV (EMP) and Group V (EMS) serve as the test group with administration of 200 mg/kg body weight (Erandmoola collected in Greeshma (EMG), Pravrut ritu (EMP) and Shishira ritu (EMS) respectively. Results: Erandamoola collected in greeshma and pravrut ritus show almost similar pain threshold with a slight increase in values than drug collected in greeshma ritu. Conclusion: Thus Erandamoola (Ricinus communis) can be efficiently used as an analgesic, simulatneously season or Samgrahana kaala is having a definite role on drug activity.