Abstract
Aim: We conducted this study with the aim to investigate the effect of vitamin D3 on spatial learning and memory in healthy young albino rat.
 Study Design: Experimental evaluation.
 Place and Duration of Study: Department of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital (SKNMCGH), Pune, between October 2019 to February 2020.
 Methodology: All the pharmacological experiments were conducted using Wistar albino rats (n=6), weighing between 100 g – 150 g. Total 18 animals (9 male and 9 female) were screened and marked into 3 different groups (6 in each group) Control (Normal saline 10 ml/kg), Vitamin D (Cholecalciferol 1000 IU/kg) and standard (Piracetam 200 mg/kg). Drugs were administered per os for 21 days. Elevated Plus Maze (Transfer Latency), Open Field Test (Rearing, Locomotion), Radial Arm Maze (Working and Reference memory) were used as amnesic models and their parameters for evaluation of this study.
 Results: After 21 days of treatment among all the three groups, Transfer Latency (p=9.55) in elevated plus maze, Working memory (p=0.454) and Reference memory (p=0.929) observed in radial 8 arm maze were non significant. In open field apparatus pellets count was significant (0.010), rest all parameters were non significant.
 Conclusion: The result of study suggests that no significant beneficial effect of Vitamin D was seen on various learning models as assessed by Elevated Plus Maze, Radial Arm Maze, Open Field Test.
Highlights
Memory is a complex function of the brain and is considered as the ability to store, retain, recall information
The result of study suggests that no significant beneficial effect of Vitamin D was seen on various learning models as assessed by Elevated Plus Maze, Radial Arm Maze, Open Field Test
This study demonstrated that Vit D had no significant nootropic effect
Summary
Memory is a complex function of the brain and is considered as the ability to store, retain, recall information. It plays a critical role in “the process of thought” which is known as cognition. Research is going all over the world to explore the neurobiology of learning and memory and to investigate agents that prevent the progression of memory loss or to improve the existing capacity. Recent studies suggest that specific nutritional factors may be linked with brain function and as such with cognitive decline [2]. Since pharmacological treatment of cognitive decline and dementia is currently far from effective at the moment, knowledge on the effect of modifiable dietary factors may bring us a step closer toward preventive solutions. Vitamin D deficiency is one of the suggested modifiable factors for brain function [3]
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