Experimental evaluation of the influence of separate administration of memantine, amantadine and solutions of magnesium sulfate on the microcirculation in the vessels of the posterior pole of the eye after a concussion

Abstract

For the first 3 hours after simulation of eye contusion in rabbits or 60 minute ischemia with subsequent reperfusion a. ophthalmica in rats, are characterized by hypoperfusion the posterior pole of eyeball. It was manifested by reliable de-escalation of microcirculation factor relatively to its baseline values on average by 8,2 times (injury) and by 39,2 times (reperfusion), respectively. Separate administration of memantine and solutions of amantadine or magnesium sulfate amortized rapid deterioration of blood supply to the eye. By the ability to improve the microcirculation of the eye in the acute post-reperfusion period a single intravenous infusion of amantadine sulfate solution (5 mg/kg intravenously (i/v)) is by 1,5 and 1,4 times better than memantine at a dose of 20 mg/kg intragastric (i/g), or magnesium sulfate (250 mg/kg i/v). In the eye contusion of rabbits, memantine oral administration or intravenous administration of amantadine sulfate in doses of 20 and 2,5 mg/kg contributed to the restoration of blood supply to the eye. This was evidenced by the growth rate relatively to the control of microcirculation pathology groups on average by 4,5 and 6,3 times with the prevalence of the drug "PK-Merz" over the drug "Mema" by 28,5 % on the value of the stimulating effects on blood flow. Improved perfusion of posterior pole of the eyeball against the background of studied modulators of the NMDA-receptor activity (memantine ("Mema") solutions amantadine ("PK-Merz") and magnesium sulfate) underlies their neuroretinoprotective effect.