Experimental Evaluation of Talisadi Suspension for Anti-Histaminic and Anti-Inflammatory Activities in Animal Models

Abstract

Talisadichoorna is a routinely used formulation among ayurvedic practitioner in disorder of Pranavaha,Annavaha and Rasavahastrotasvyadhi’s. As choorna has some drawbacks, as a dosage forms talisadichoornawas converted into a modern dosage form i.e. suspension. It is better than choorna in aspects like ease inadministration, longer shelflife and faster absorption. Standard Operating Procedure was followed for itspreparation. No work was reported regarding its pharmacological action except for anti microbiologicalstudy.This study aimed to assess its anti inflammatory and antihistaminic actions, which is clinically seen. Thisstudy helped in assessing mode of action of the formulation. The disease Tamak shwas can be correlatedwith Bronchial Asthma on the basis of pathology, signs and symptoms. Bronchial Asthma is characterisedby dyspnoea, excessive cough, wheeze, chest tightness etc caused by airway inflammation and increasebronchial responsiveness. To study antiinflamtoamry activates model selected was “Granuloma pouchmodel” using rats as experimental animals. To study antihistaminic activity experimental animal guinea pigwas used and model used was “Protection against histamine induced brochospasm model”. It was evidentthat Talisadi Suspension exhibit significant anti-inflammatory and antihistaminic activities.