EXPERIMENTAL EVALUATION OF CHRONIC ORAL TOXICITY AND LONG-TERM EFFECTS OF SOLID ROCKET FUELS COMPONENT

Abstract

The chronic oral toxicity and long-term effects of the basic lead-nickel salt of phthalic acid have been investigated by long-term oral ingestion of white outbred rats. The compound at doses of 1.0 mg/kg; 0.3 mg/kg and 0.1 mg/kg have changed the physiological, behavioral, hematological, biochemical, immunological parameters, as well as the relative weight of internal organs of animals in the six months experiments. The threshold of chronic oral toxicity of the substance is set at 0.1 mg / kg.The study of long-term effects revealed the absence of its mutagenic activity both at the gene (Ames test) and chromosomal (dominant lethal method) levels. In addition, the analyzed compound did not adversely affect the reproductive function of male rats. When entering the body of females during gestation, the toxicant did not reveal embryo-lethal and teratogenic properties.However, chronic administration of the compound into the body of non-pregnant animals at a dose of 1.0 mg/kg contributed to a significant decrease relative to the control of the mass and disk diameter of the placenta, which indirectly indicated the functional inferiority of the organ. Therefore, the considered level of the substance is defined as a threshold for gonadotoxic effect.The obtained data are taken into account in developing of hygienic standard of the estimated component of solid rocket fuels in water reservoirs.