Experimental Evaluation of Antidepressant activity of Aqueous and Chloroform Leaf and Shoot Extracts ofEicchornia crassipesLinn in Mice

Abstract

The main objective of the study to evaluate the Anti-depressant activity of aqueous and chloroform extract of Eicchornia crassipes in Forced swim test (FST), Tail Suspension test (TST) in mice. Phytochemical screening showed presence of carbohydrates, alkaloids, flavanoids, steroids, saponins, amino acids, gums and mucilage. AEEC and CEEC did not produce any lethal effect even upto 2000mg/kg, p.o during Acute Oral Toxicity study. In FST and TST, CEEC showed diminution of duration of immobility time in 200mg/kg but not in 100mg/kg. From the above finding concluding that, shortening of immobility time in the FST and TST indicating, CEEC showed more antidepressant activity acting either by the enhancement of central 5-HT or catecholamine neurotransmission compared to AEEC in mice.