Abstract
The production of inflammatory cell infiltrations within popliteal lymph nodes regional to challenged subcutaneous foot pad sites served as an experimental model for evaluating possible eosinotactic stimuli in the guinea pig. The following were studied: purified native serum gamma globulins of bovine (BGG), rabbit (RGG), and guinea pig (GPGG) origins; chemically altered gamma globulins in aggregated states (AgBGG, AgRGG, AgGPGG) and in urea-treated denatured forms (DeBGG, DeRGG); preformed soluble BGG antigen-antibody complexes; and BGG antigen-rabbit antibody systems in passive sensitization procedures. Cellular responses were evaluated by microscopic study of lymph node smear preparations and by histologic sections. Significant degrees of eosinophil granular leukocyte infiltrations were found in the sinuses of lymph nodes of guinea pigs receiving AgGG of both foreign and homologous species origins, DeBGG and DeRGG, soluble antigen-antibody complexes, and of those subjected to antigen-antibody reactions. Lesser degrees of involvement demonstrated in animals receiving native gamma globulins were attributed to the content of altered forms in these preparations. Specific in vivo antigen-antibody reactions were additionally characterized by associated polymorphonuclear granular leukocyte responses within cell infiltrates. The emergence of eosinophilia did not depend upon any potential associated role for the inflammatory stimulus as an immune reactant. These findings suggest that eosinotactic influences of antigen-antibody union may be related to the presence of antigen-antibody complexes in the form of molecular aggregates.
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