Experimental Emphysema

Abstract

The synthesis of nano eight-armed poly{POSS lactide-b-N, N-(dimethylamino)ethyl methacrylate} copolymers is reported in this paper. Thio-click chemistry combined with living/controlled polymerization methods that allow the preparation of well-defined polymeric building block copolymers. This was carried out using Thio-Click reaction of octavinyl POSS with 2-mercapto ethanol to prepare Thiolate-POSS. Thiolate POSS-lactide polymers containing different l-Lactide repeated units (10, 25, 50 and 100) were synthesized by ring-opening polymerization of (l-lactide) in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as a catalyst. The resulting polymers were copolymerized with N-hydroxyethyl-2-(dimethylamino) ethyl methacrylate (DMAEMA) via atom transfer radical polymerization. All the prepared polymers and copolymers are characterized by different spectroscopic and analytical techniques, such as infrared spectroscopy, nuclear magnetic resonance (1H NMR and 13C NMR) and by gel permeation chromatography (GPC), where all these analyses have verified the expected structure and compositions. On the other hand, images obtained from Scanning Electronic Microscopy (SEM) revealed the existence of nanostructures in the prepared copolymers due to the presence of the lactide array to give nanofiber within final compositions prepared, and with the presence of POSS in their structures, they enhance the copolymers thermal stability, and they are expected to be suitable for different applications as nano-carriers in the biomedical field.