Abstract
ABSTRACTThe solubility of bosentan (BST) in the aqueous mixtures of polyethylene glycol 200 (PEG 200) at the temperature range, T = (293.15–313.15) K, has been studied using a shake-flask method. The experimental solubility data were correlated with Jouyban–Acree, Jouyban-Acree-van’t Hoff, modified Wilson and Yalkowsky models. Deviations of the calculated solubility from experimental one were determined by percent average relative deviations and relative deviations. In addition, to represent the thermodynamic behaviour of BST in PEG 200 solutions, the apparent thermodynamic functions, Gibbs energy, enthalpy and entropy of dissolution were obtained by using the van’t Hoff and Gibbs equations.
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