Abstract
ABSTRACT Fracture in the hip joint is a major and quite common health issue, particularly for the elderly. The loads exploited by the lower limbs are very acute and severe; in the femur, they can be several folds higher than the whole weight of the body. Nanotechnology and nanocomposites offer great potential in biomedical applications. The organic materials are more biocompatible. Mechanical properties like strength and hardness are challenging parameters which control the selection of a joint. HDPE in its pure form has been successfully used as a prosthetic foot (external) but failed as an implant material due to limited mechanical properties. High-density polyethylene thermoplastic polymer (HDPE) and multi-walled carbon nanotubes (MWCNT)/Nano-Alumina is selected as a potential material for a biomedical implant and its mechanical properties and biocompatibility have been discussed. HDPE/MWCNT/Alumina (Al2O3) nanocomposites have not been explored yet for prosthetic implants. These nanocomposites were prepared in this investigation in different compositions. Prepared material has been physiochemically characterized to check the morphology and the structure. MWCNTs enhanced hardness and elastic modulus of the HDPE. Optimization of the material composition revealed that hybrid composite with structure (2.4% Al2O3 and 0.6% MWCNT) exhibits better mechanical properties compared to other ratios with 3% MWCNTs and 5% MWCNTs. Thermal gravimetric analysis (TGA) dedicates that the percentage of crystallization has been increased to 6% after adding MWCNT to HDPE. The moisture absorption decreased to 90% with 5% MWCNT. Experimental results of Colorimetric assay (MTT) of a normal human epithelial cell line (1- BJ1) over Al2O3/MWCNT@HDPE showed <20% cytotoxic activity, proving its acceptance for medical use. HDPE/MWCNT/Al2O3 nanocomposites emerged as a candidate material for artificial joints.
Highlights
Hip joint represents a major health challenge facing medical society nowadays
Thermal gravimetric analysis (TGA) dedicates that the percentage of crystallization has been increased to 6% after adding Multi-wall carbon nanotubes (MWCNT)to the polymer
In summery HDPE Polymeric nanocomposite has been reinforced with MWCNTs and alumina by using a wet chemical approach
Summary
Hip joint represents a major health challenge facing medical society nowadays. The hip prosthesis is the greatest key factor of biomaterial fabrication to meet the requirements of joint arthroplasty. Massive loads experienced by the limbs are very dangerous. Abnormal combinations of mechanical and physical characteristics are the main parameters that control the quality and feasibility of the hip joint. Toughness, tailored stiffness, resistance to impact and corrosion are examples of those combinations relevant for tissue substitute structure. Many polymers are broadly utilized to be applied in this direction due to wide classification of chemical compositions, characteristics, feasibility and biocompatibility[1,2,3]
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