Abstract
It is we11 accepted that hemodynamics plays an important role in atherogenesis in man. However, the precise mechanisms have not been elucidated yet. Recently, Karino et al. hypothesized that flow-dependent concentration polarization of low-density lipoproteins (LDL) may occur at a blood / endothelium boundary, leading to a high risk of atherogenesis in regions of low wall shear rate where the concentration of LDL builds up. In this study, we attempted to experimentally confirm their predictions by optically measuring the concentration profile of polystyrene latex microspheres in a suspension flowing through a dialysis tube. It was found that the surface concentration of microsphere certainly increases with decreasing the flow rate and it occurs even under the condition of a very low water filtration velocity encountered in normal arteries in vivo, giving a strong support to the hypothesis proposed by Karino et al.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
