Abstract
Aim: The choice of graft materials used for spinal fusion possesses a great importance due to their crucial roles in bone remodelling. Autogenous bone grafts are known as the "gold standard" in spinal fusion surgeries. Studies on synthetic graft materials that can be used instead of autogenous bone grafts have gained importance in recent years. The aim of this study was to compare the efficacy of demineralized bone matrix and autograft in the rabbit spinal lumbar fusion (SLF) model.
 Methods: Twenty New Zealand rabbits were randomly divided into two groups and underwent SLF by using either iliac crest autologous bone graft (Autograft, n=10) or DBM Flex (Grafton, n=10). Eight-weeks after surgery, animals were sacrificed and spinal fusion was evaluated by computerized tomography (CT), manual palpation, macroscopic analyses, and histological assessments.
 Results: CT results revealed that autograft led to significantly higher fusion scores than DBM Flex (p=0.0004). Mobility was significantly lower in autograft group (p=0.0007). Significantly lower bone formation scores were observed in DBM Flex group compared to autograft group (p
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