Abstract
The rather extensive studies of Hall et al1 and Fairburn and Semple2 indicate that penicillin, streptomycin, oxytetracycline,chlortetracycline,and chloramphenicol have little effect in altering the course of acute leptospirosis in humans. However, a number of investigators have demonstrated that penicillin, streptomycin, oxytetracycline, and chlortetracycline are effective in the treatment of leptospirosis in laboratory animals if therapy is initiated before severe clinical manifestations become apparent.3-17 Chloramphenicol has been
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