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Abstract
Background: Mandibular reconstruction, after extensive resection of the mandible for the treatment of oral cancer, is a well-known procedure, however, relatively little is known about bone integration into the titanium implant after reconstruction with a temporary plastic implant. The main goal of this experimental study was to study the process of osseous integration into the titanium implant in an in vivo experiment following prior mandibular reconstruction with a temporary plastic implant. Materials and Methods: Four ewes initially underwent a partial one-sided resection of the mandible, with the formation of an approximately 3 × 1 cm defect. All of the subjects received reconstruction with an implantation of a plastic plate (3 cm). The plastic plate was removed and replaced by a titanium implant at 1, 3, 6, and 12 months, accordingly. Both plastic and titanium implants were made via 3D-printing technology and personalized modeling. A total of 6 months after titanium implantation, a histological evaluation of biointegration was performed. Results: All surgeries were uncomplicated. The integration of osseous tissue into the titanium implant was seen in all cases. Histologically, each case showed variable integration of dense fibrotic tissue with fibroblasts and non-mature bone tissue with a definitive layer of bone matrix with many osteoblasts on the periphery. The prior implantation of the plastic plate did not interfere with bone integration into the titanium implant. Conclusion: Preliminary results demonstrated that a temporary plastic implant for mandibular reconstruction does not interfere with the consequent osseous biointegration of a permanent titanium implant. This shows that temporary reconstruction is a safe solution when delayed mandibular reconstruction is required due to disease severity.
Highlights
Mandibular defects after extensive resection, due to tumors and other pathology, are quite disfiguring and can lead to significant cosmetic and functional deficiency
There are a few case reports, clinical studies, and experimental studies regarding the use of porous titanium implants in the reconstruction of the mandible as primary surgery [1]
No significant scientific input into investigating bone integration in was the titanium implant infection was controlled, true reintegration of osseous tissue appears to be more difficult to positioned after previous surgical trauma or after explanting a temporary prosthesis has been carried achieve
Summary
Mandibular defects after extensive resection, due to tumors and other pathology, are quite disfiguring and can lead to significant cosmetic and functional deficiency. There are a few case reports, clinical studies, and experimental studies regarding the use of porous titanium implants in the reconstruction of the mandible as primary surgery [1]. Bone formationThis was shows that titanium mandibular implants, in complex surgeries, remain proven after the infection was controlled, true reintegration of osseous tissuecontroversial.
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