Experimental assessment of efficiency of new domestic local haemostatic means on the basis of chitosan

Abstract

One of the main reasons for the death of potentially wounded military personnel on the battlefield is ongoing bleeding. In recent years, with the advent of a new group of local hemostatic drugs, the results of prehospital care with external massive bleeding have improved significantly. At the same time, local haemostatic agents based on chitosan showed the greatest effectiveness. The results of the experimental evaluation of the effectiveness of new local haemostatic agents based on chitosan: «Gemohit» (powder, 20 g in the package) and «Hemohit-bandage» (a bandage in the z-fold, 8×150 cm) using the model of external massive arterial bleeding in sheep according to the variant of marginal femoral artery injury. Some of the tests were carried out after 3 years of storage of the preparations (3 samples) and under ambient conditions minus45°C (2 tests). It was found that with external massive arterial bleeding, the use of powder and bandage in the z-fold ensured survival of the animals in 100% of cases, primary and final hemostasis was achieved in 50 and 100% of cases, respectively. Storage for 3 years, as well as use of the drug at low ambient temperature does not reduce its effectiveness. The use of local haemostatic agents «Gemohit» and «Hemohit-bandage» is not accompanied by side effects (local hyperthermal reaction, distal or proximal embolism of blood vessels). Local haemostatic funds «Gemohit» and «Gemohit-bint» showed high efficiency in the experimental model of massive external arterial bleeding. Using the local hemostatic agent «Gemohit» in the form of a bandage is more promising in terms of convenience and effectiveness than the use of powder.