Experimental Animal Models in Heart Disease

Abstract

Heart diseases constitute a significant global burden of mortality and morbidity. This encompassing word refers to a variety of illnesses, including coronary artery disease, heart failure, myocardial infarction, and valvular heart disease. Given the imperative need to comprehend and address these ailments, experimental studies are indispensable. Experimental animal models serve as indispensable tools in elucidating the mechanisms of heart disease. They are pivotal for developing novel treatments and assessing the efficacy of existing therapies. Among the commonly utilized animal models in heart disease research are mice, rats, rabbits, dogs, and pigs. Each model offers distinct advantages and limitations, allowing researchers to probe specific facets of cardiac pathology and unravel the intricate mechanisms involved in heart disease. In this comprehensive review, it was aimed to provide a succinct overview of the various animal models employed in heart disease research. The advantages and drawbacks of each model were delineated, the aspects of human heart disease they emulate were elucidated, and pivotal research findings facilitated by their utilization were highlighted. By synthesizing this information, it was the endeavor to provide researchers and clinicians with valuable insights into the diverse array of animal models available for investigating heart diseases, ultimately paving the way for enhanced understanding and treatment of these debilitating conditions.