Abstract
AbstractThe electrochemical oxidation of DNA and bases at a glassy carbon electrode were investigated using cyclic and square-wave voltammetry analysis. The predicted oxidative potentials for DNA and bases using DFT method (B3LYP) are in agreement with the experimental ones.The DNA oxidation ascribes to N-protonated guanine and adenine. The calculated oxidative peaks indicate that the initial potential of DNA oxidation is around 0.432V for N-protonated guanine and 0.368V (vs.hydrogen standard electrode) at pH 7.00, and DNA as well as bases in acidity solution are more stable than those in alkalescent solution.
Highlights
The electrochemical oxidation of DNA and bases at a glassy carbon electrode were investigated using cyclic and square-wave voltammetry analysis
More than 60 different base lesions have been identified, DNA oxidation is a dangerous factor leading to cancer[1]
The peaks of GH2/GH1, GH3/GH2,A2/A1 and A3/A2 in the cyclic voltammetry (CV) and Square-wave voltammetry (SWV) are not observered the initial potential of N-protonated guanine and adenine oxidation in DNA is around 0.432 and 0.368V vs. hydrogen standard electrode at pH 7.00, respectively, indicating that the factor of catalyzed these reactions of DNA bases is dangerous,or the potential of a couple electrode higher than this level is dangerous
Summary
The electrochemical oxidation of DNA and bases at a glassy carbon electrode were investigated using cyclic and square-wave voltammetry analysis. The batteries reactions in gas state of N-protonated guanine and adenine is calculated as above method.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
