Abstract
Peritoneal exudate cells of rats with experimentally acquired antl Yoshlda sarcoma were intravenously transferred Into Yoshida sarcoma bearing rats. The mode of growth of subcutaneous nodules in the back of these recipient rats as well as the histological picture were studied.Transfer of 5 × 106 peritoneal exudate cells of rats with anti‐Yoshida sarcoma resulted in temporary growth inhibition of tumor nodules in 50% of the rats. Transfer of 8 × 106 cells resulted in the disappearance of tumor nodules in 60× of the rats. Histological picture obtained daily revealed marked inntration of large mononuclear cells and lymphocytes in tumor nodules especially in the peripheral portion. In the sections stained with silver impregnation, amoeboid and branching metallophillc cells were abundantly found in the peripheral portion of the subcutaneous nodule. Round and amoeboid metallophillc cells corresponded to large mononuclear cells. In the rats in which the tumor disappeared, scarring was noted. Follow‐up studies of the peritoneal exudate cells labeled with 3H‐thymidine of rats with anti‐Yoshida sarcoma revealed that very little remained of the portion in the interstitium tissue around the tumor on the second day and none at all in the tumor on the 5th day.
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