Abstract
Phytomediated selenium-copper oxide (Se-CuO) and selenium-zinc oxide (Se-ZnO) nanoparticles (NPs) were studied for their biological activities in microbes and the MCF-7 breast cancer cell line. Cassia angustifolia seed was used to prepare selenium supported metal oxide nanoparticles (Se-MO NPs). The Se-MO NPs were characterized with UV-DRS, FT-IR, XRD, Raman, XPS, and HRTEM techniques together with computational studies of the structures, electronic and vibrational spectra of model clusters. Experimental spectra and observed structural features were assigned with the aid of quantum chemical studies. The minimum inhibitory concentrations (MIC) for the Se-MO NPs were determined which reveal that the Se-ZnO NPs have the highest antimicrobial activity. The IC50 values were determined using different doses of Se-MO NPs on MCF-7 and the results reveal that Se-CuO NPs exhibit enhanced anticancer activity due to their low hardness and electronic features as inferred from their electrostatic potentials and frontier orbitals. The observed biological activities of Se-MO NPs were interpreted on the basis of molecular structures, nanoparticle sizes, surface imperfections, and morphologies.
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