Abstract
Gliclazide (GLC) inclusion complexes with β-cyclodextrin (βCD) were studied by UV–VIS and FT-IR spectroscopy. The recorded spectra confirmed formation of GLC-βCD binary complexes and GLC-(βCD)2 ternary complexes in aqueous solutions. UV–VIS measurements carried out for a number of temperatures allowed to determine the binding constants of the complexation reactions. The bioavailability of GLC-βCD and GLC-(βCD)2 was determined using the n-octanol/water partition coefficient. Experimental studies were supplemented with theoretical calculations. Quantum-chemical calculations and classical molecular dynamics simulations were used to describe the interactions in the host-guest inclusion complexes.
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