Abstract
AbstractInhalation exposure chambers may be used for in vivo drug delivery or toxicological assessments among other applications. Nose-only exposure chamber (NOEC) systems limit non-respiratory aer...
Highlights
A variety of inhalation exposure chambers are used for in vivo drug delivery or toxicological and safety assessments in rodents
Test guidelines published by the Organization for Economic Co-operation and Development (OECD) expressly mention two types of exposure systems: whole-body exposure chambers (WBEC) and noseonly exposure chambers (NOEC) (OECD GD 39, OECD TG 403)
In the whole-body exposure chamber, the animal is free to move inside a restraining cage of defined area and volume while the entire body is exposed to the test atmosphere
Summary
A variety of inhalation exposure chambers are used for in vivo drug delivery or toxicological and safety assessments in rodents. The chambers differ by the portion of the animal body that is in direct contact with the exposure atmosphere (Phalen 1997). Test guidelines published by the Organization for Economic Co-operation and Development (OECD) expressly mention two types of exposure systems: whole-body exposure chambers (WBEC) and noseonly exposure chambers (NOEC) (OECD GD 39, OECD TG 403). In the NOEC, the animal’s movements are restricted, and the system apparatus is constructed so that, optimally, only the nose/snout is in contact with the test atmosphere. The aerosol in the WBEC is in contact with the animal environment and can be altered by the animal’s activities and bodily output or absorbed by non-respiratory routes, leading to a dose alteration and potentially affecting analyses of biological responses.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
