Abstract
The study aims to perform experimental and clinical testing of the effect of the milk product “Bulgaricum” containing Lactobacillus Bulgaricus (LB) strain GB N 1 (48) on the progress and severity of experimental model of hyperlipidemia and sclerotic processes serum lipids and blood flow in aa. carotides in persons with dyslipoproteinemia (DLP). Histological and electron microscopic examinations of the components of the major intercellular matrix of rat myocardium and aorta slices evidence the combination of atherogenic diet and the milk product “Bulgaricum” leads to a delayed synthesis of collagen proteins, a tendency of decreased deposition of insoluble collagen, and improved ratio of unsulfated and sulfated glucoseaminoglycanes. Doppler sonography, and serum lipids studies in 26 individuals with DLP and ischaemic heart disease after 3 months supplementation with the product indicated substantial decrease of TC and LDL-Chol. The milk product “Bulgaricum” has hypolipidemic and antiatherosclerotic effect in humans and animals.
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