Experimental and clinical observations on the use of pericranium in inhibiting bone regrowth and fusion.

Abstract

HE usual surgical treatment of craniosynostosis involves a simple linear craniectomy followed by wrapping of the bone edges with some material to inhibit bone regrowth and fusion, s,9 Fibrin film, oxidized cellulose gauze (Oxycel), tantalum, methyl methacrylate (Lucite), rubber, and polyethylene (Polythene) have been used in an attempt to inhibit bone regrowth and fusion after linear craniectomies. 1,2,1~ Anderson and Johnson 2 described the use of Zenker's acetate solution or 7 % tincture of iodine on the surgically exposed dura mater, with favorable results. Linear craniectomy followed by the application of polyethylene and/or Zenker's solution is now the commonly accepted treatment for this condition? ,s,9,12,17 Complications that can occur with this method of treatment are foreign body reactions, infections, and the late possibility of neoplasm productionY ,3,5,a2,14 Sorour in 1961 was the first to use pericranium interposed in craniectomies done for craniosynostosis. He used this in conjunction with an initial four-flap operation and, most recently, a bilateral flap operation.,,~,l.6 This experimental study was undertaken to determine if pericranium interposed between the fracture edges inhibits bone regrowth and fusion in the first year of life in dogs.