Abstract
Objective To establish reliable spinal cord injury (SCI) models in rodents for pathological/physiological changes after spinal cord injury to formulate standard models and provide reasonable prospects for new treatment strategy. Methods Sixty female SD rodents were randomly divided into model group and fake-operation group. In model group, SCI models were established in SD rodents at T10 segment via Hatteras PCI3000 instruments. At 1st, 3rd, 7th, 14th and 28th days after operation, spinal tissue analysis for neural necrosis rate and NF-200 expression were performed and analyzed after evaluating movement of posterior limbs by basso beattie bresnahan (BBB)scale in 6 rodents from 2 groups. Results In model group, BBB scale decreased greatly after operaton along with inferiority in comparison with fake-operation group (P=0.000). In fake-opeation group, necrosis index was inferior yet NF-200 expression was higher than model group (P=0.000). Conclusion Hatteras PCI3000 instruments contributes to establishing reliable SCI models by accurate and metrizable, controllable and repeatable punching. Key words: Rodent; Spinal cord injury; Model
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