Abstract
SummaryRenal adenocarcinomas can be induced in Rana pipiens with equal success after injection of virus containing cell fractions derived from either the cytoplasmic or nuclear portion of renal tumor cells with intranuclear inclusions. The latter result supports the contention that a nuclear herpes-type virus (HTV) is implicated in tumor induction. Brief periods of sonication do not alter the oncogenicity of either cell fraction. Pretreatment of the viral cell fractions with a proteolytic enzyme or lyophilization of the fractions prior to injection destroys all oncogenic action. Postinjection heat shock of the injected embryos also prevent the formation of renal tumors. Postinjection cold treatment of induced tumors results in formation of intranculear inclusions, an index of viral replication.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
