Abstract
Antigen-induced suppression and therapy of experimental allergic encephalomyelitis in Lewis rats was studied using guinea pig myelin basic protein administered either intravenously or intraventricularly. A small intraventricular dose of basic protein was effective when given shortly before the onset of clinical signs (suppression) as well as when given after the disease (therapy). In contrast, the same amount of basic protein administered intravenously was effective only in the therapy of disease.
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