Abstract
The acne varioliformis referred to in this study is that of the Hebra, i. e., the more widespread, deep-seated, indurative form followed by varioliform scars. Case 1 was of the extreme type, both as to distribution and character of lesion. Case 2 was more limited. However, common to both cases were the indurative, woody edema, hemorrhagic deep necroses and correspondingly deep varioliform scarring that are not seen in the acne necrotica of Boeck. Our experiments were confined to reproduction of the lesions, but nothing was done to ascertain their distribution. The lesions were produced both in guinea-pigs and in the patient himself with the streptococcus associated with the staphylococcus. I believe that the streptococcus is to be looked on as the agent that caused the distinctive features of the lesion in the two cases reported. REPORT OF CASES Case 1.— Nicholas F., a youth, aged 18, white, of Italian parentage,
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