Abstract

At the beginning of the nineteenth century, the Spanish Crown extended the use of cowpox as a vaccine against smallpox to its subjects around the globe. As the first global public health initiative, the smallpox vaccination campaign presents a prime opportunity to reconsider the global early modern through an analysis of the relationship between the global imperial structures through which the vaccine was conveyed and the varied local responses to vaccination. In fact, the vaccination campaign prompted a complex and dynamic interchange between the global and the local over issues as diverse as the relationship between subject and king, hierarchies of medical knowledge and authority, and expectations about maternity and motherhood.

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