Abstract
Xylene, a chemical used extensively in histology and cytology laboratories for tissue processing and slide staining, has a long-standing record as a possible health hazard. Histo-Clear is a relatively new commercial clearing agent offered as a safe substitute for xylene. The author found that the ease of microtomy was improved with certain tissues that were “cleared” in Histo-Clear. Unacceptable results were obtained, however, when Histo-Clear was sed in place of xylene in the routine hematoxylin and eosin and Papanicolaou staining procedures.
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