Abstract
Dengue, Chikungunya and Zika infections occur in tropical and subtropical regions. We illustrate the application of an in-house multiplex NAT targeting these arboviruses for returning travellers in Alberta, Canada. NAT was performed until 40 days from symptom onset due to protracted Zika viruria. From 1 September 2017 – 31 August 2019, 2552 specimens from 1932 patients were tested. Approximately 2% of travellers were NAT positive for dengue (n=42), Chikungunya (n=4), and Zika (n=1). Major symptoms were fever, myalgia and rash.
Highlights
The Royal College of Pathologists of Australasia Quality Assurance Programs (RCPAQAP) offers external quality assurance (EQA) for pathology laboratories in Australia and over 60 other countries
An external quality assurance program is being explored with RCPAQAP to ensure comparable resistome results are obtained
As we celebrate 100 years since the first use of the bacillus Calmette-Guérin (BCG) vaccine, the only licensed vaccine against tuberculosis, this is an opportune time to examine the current state of tuberculosis vaccine development
Summary
The Royal College of Pathologists of Australasia Quality Assurance Programs (RCPAQAP) offers external quality assurance (EQA) for pathology laboratories in Australia and over 60 other countries. A CDGN sub-committee with NTAC and other representatives has: surveyed TB WGS in the jurisdictions; compared methodologies; and optimised formats for reporting TB WGS results to clinicians and the state TB Units. An external quality assurance program is being explored with RCPAQAP to ensure comparable resistome results are obtained. With a better understanding of the host innate and adaptive immune response to infection and how Mycobacterium tuberculosis grows and subverts this response, vaccines are being made to accommodate use in different populations.
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