Abstract
Recsod? has been used for treating epilepsy and ophthalmological disease. Oxidative stress has been demonstrated to be a pathogenic chain of these diseases. Parameters of pro- and antioxidant systems were studied in all the patients treated. Recsod? drug was shown to produce positive effect in all the patients. Improvement of patients’ clinical condition correlated with an increase in antioxidant activities. Antioxidants, in particular, the recombinant human SOD drug, proved to be effective in treatment of some neurological and ophthalmological diseases.
Highlights
Metabolic processes in tissues are accompanied by generation of highly reactive oxygen species (ROS)
Several parameters of free radical oxidation and of AO system were evaluated in all the patients with dry age-related macular degeneration (AMD) and in healthy volunteers (Table 1)
Intensive generation of ROS may be caused by tissue energy metabolism disturbance in development of macular degeneration, primary open-angle glaucoma associated with tissue hypoxia during aging or with energy consumption jump and its quick depletion at epileptic seizure
Summary
Metabolic processes in tissues are accompanied by generation of highly reactive oxygen species (ROS). The intensive ROS generation at different pathologies causes oxidative destruction of proteins, lipids, nucleic acids, and carbohydrates. Toxic effects of ROS are prevented by antioxidant protection (AOP), which involves enzymes and nonenzymatic components. Effects of enzymatic antioxidants are closely connected with each other and accurately balanced among themselves [1] [2]. Each tissue possesses a certain buffer capacity for AOP, represented by AOP of intracellular fluid and of a cell itself. Some tissues due to special features of their functional and metabolic activities possess hypersensitivity to oxidative stress (OS).
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