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Abstract
BACKGROUND: Over the past ten years, there has been a persistent increase in the resistance of dermatophytes to antifungal drugs. The development of new drugs and the evaluation of the effectiveness of medicines is a priority in mycology.
 AIMS: Evaluation of the effectiveness and safety of using the cream containing Tetranyl U and 10% urea in the treatment of tinea corporis and tinea cruris.
 MATERIALS AND METHODS: The study included 30 patients with a laboratory-confirmed diagnosis of tinea corporis and tinea cruris of mild to moderate severity. Patients were recommended to use the cream which was applied to the lesions 2 times a day for 3 weeks. The evaluation of the severity the course of mycosis and the effectiveness of the cream was carried out by calculating a 4-point PGA (Physician Global Assessment) before treatment and after 3 weeks of using the cream.
 RESULTS: According to the results of the study, the clinical efficacy was 81.8%. Mycological response (negative direct microscopy + mycological culture) was achieved in 82.8% of patients.
 CONCLUSION: The cream containing Tetranyl U showed good efficacy and tolerability in the treatment of tinea corporis and tinea cruris, which is confirmed by the results of clinical and microbiological studies.
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