Experience of the combined use of the cusp-overlap projection and auricular pacing in transcatheter aortic-valve replacement with the self-expanding valves

Abstract

Abstract Introduction Need of permanent pacemaker implantation (PPI) continues to be an undesirable side-effect after transcatheter aortic-valve replacement (TAVR), mostly in self-expandable (SE) valves. Recently, different techniques have arisen, as the cusp-overlap projection (COP) to better control TAVR implantation depth, and the sequential atrial pacing (AP) after deployment to test atrioventricular (AV) conduction. However, the combination of both techniques has not been tested yet. We sought to determine if the combination of COP and AP can decrease the need of PPI after SE aortic prothesis. Methods We retrospectively studied 253 patients in sinus rhythm who underwent TAVR procedure with SE valves between 2018 and 2021, and compared standard implantation (n=143) with the combined use of COP and AP (n=110). Patients with permanent atrial fibrillation or previous pacemaker were excluded. Assessment included EKG, imaging, immediate and 30-day follow-up. AP was performed after TAVR in the absence of complete AV block at rates of 70 to 120 beats/min (or until AV Block was observed). Results Median patient age was 80 [75–85] years old and 52.2% were female. No significant differences could be appreciated in baseline demographics or treatment. Both cohorts had similar EKG intervals and similar rates of conduction disturbances (Table 1). Patients with CO+AP displayed bigger outflow tract perimeters (p=0.003). Also, the CO+AP cohort underwent more frequent predilation prior to valve deployment (p<0.001). During TAVR complete AV block occurred in 4.6% of the CO+AP cohort vs 14.8% in the standard group (p=0.002). Among patients with transient or no conduction disturbances immediately after deployment, AP showed Wenckebach phenomenon in 22 subjects at a median heart rate of 110 bpm. PPI was considered within 24 hours when Wenckebach phenomenon developed below 90 bpm. Testing atrio-his conduction led to a significant decrease in the next 24-hour surveillance with a temporary pacemaker in the COP+AP cohort (23.1% vs 90.2% in the standard cohort, p<0.0001). Time of hospitalization was significantly reduce in the COP + AP cohort (mean stay 2 [1; 3] days vs 5 [4; 8] days in the standard cohort, p<0.0001), and the total amount of total PPI at that time was still lower CO+AP group (12.7% in CO+AP group vs 21.0% in the standard, p=0.121) (Figure 1). On a 30-day follow-up, the rate of PPI after TAVR remained significantly decreased in the COP+AP cohort (p=0.039, Figure 1). Conclusion Combining COP with AP reduces the need of immediate and short-term PPI and reducing on-admission conduction surveillance and hospitalization stay after self-expandable TAVR. Funding Acknowledgement Type of funding sources: None.