Abstract
HCV infection is one of the most common causes leading to the development of terminal liver diseases – cirrhosis and hepatocellular carcinoma, the main treatment for which is orthotopic liver transplantation. However, with continued virus replication, 100% reinfection occurs, which leads to the rapid progression of cirrhosis of the graft and the loss of its function. Standard interferon-containing therapy is ineffective for HCV infection, especially genotype 1, both before and after transplantation, and also has a wide range of adverse events. The article presents the successful experience of treating the recurrence of HCV infection 1 genotype in a patient who underwent liver transplantation and several courses of ineffective antiviral therapy.
Highlights
HCV infection is one of the most common causes leading to the development of terminal liver diseases – cirrhosis and hepatocellular carcinoma, the main treatment for which is orthotopic liver transplantation
With continued virus replication, 100% reinfection occurs, which leads to the rapid progression of cirrhosis of the graft and the loss of its function
Standard interferon-containing therapy is ineffective for HCV infection, especially genotype 1, both before and after transplantation, and has a wide range of adverse events
Summary
Стандартные схемы противовирусной терапии (ПВТ) на основе препаратов интерферона и рибавирина, широко применявшиеся для лечения HCV-инфекции, имеют ряд ограничений после трансплантации печени. Указанные схемы применяются и у реципиентов печени для лечения рецидива HCV-инфекции, что приводит к значительному улучшению отдаленных результатов трансплантации у данной категории пациентов.
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