Abstract
The paper describes experience with intravenous thrombolysis used in a few vascular centers of the Republic of Tatarstan in the past 5 years. Intravenous thrombolysis with alteplase (actilise) was carried in 300 patients (188 men and 112 women) aged 21 to 79 years (mean age 59.8±13.7 years) who had ischemic stroke (IS). Significant positive changes (a neurological deficit decrease on the NIHSS score by ≥ 4 points) were observed in 67.3% of cases; mortality was 6.7%. Hemorrhagic events as asymptomatic hemorrhagic transformations were found in 19.3% of cases with the neurological disorders being progressive in 4.6%. Recanalization of internal carotid artery occlusion was recorded only in 24.0% of the patients and that of occlusion of the proximal segments of the middle cerebral artery was in 50.1%. Examples of effective intravenous thrombolysis in IS in the carotid and vertebrobasilar beds are given. Whether intravenous thrombolysis can be more extensively used in IS is discussed.
Highlights
The paper describes experience with intravenous thrombolysis used in a few vascular centers of the Republic of Tatarstan in the past 5 years
Hemorrhagic events as asymptomatic hemorrhagic transformations were found in 19.3% of cases with the neurological disorders being progressive in 4.6%
Whether intravenous thrombolysis can be more extensively used in IS is discussed
Summary
Однако при этом летальность в группах тромболизиса и плацебо существенно не отличалась как через 3 мес (соответственно 17 и 20%), так и через 1 год после развития инсульта (24 и 28%). До начала тромболитической терапии неврологический дефицит колебался от 4 до 23 баллов (в среднем 12,6±5,5 балла) по шкале тяжести инсульта Национального института здоровья США (NIHSS).
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