Abstract
Our goal was to analyze the possibilities of improving the diagnostics of CSS and to improve the effectiveness of treatment according to the existing literature and our own experience of long-term care for patients with eosinophilic granulomatosis with polyangiitis or Churg-Strauss syndrome (CSS). The medical histories of three female patients aged 26 to 46-years and a 20-year-old male patient were considered. The duration of the disease before the established diagnosis was 5-17 years. Anamnesis and medical documents analysis showed a typical CSS debut in the form of allergic rhinitis, nasal polyps, which were recurrent after polypectomy, and respiratory disorders, which were regarded as bronchitis or bronchial asthma – corresponding to the first phase, also called the prodromal or allergic stage of CSS. The prodromal period lasts up to 10 years or more and is characterized by various allergic manifestations, more often – pollinosis or bronchial asthma, that is difficult to control. But CSS can be suspected because of low effectiveness of the therapy with inhaled steroids, lack of effect of antibiotics and eosinophilia more than 10% that occurs periodically. Even in the third stage of CSS in systemic manifestations of vasculitis and severe secondary lesions of organs and tissues with functional impairment, constant intake of maintenance doses of corticosteroids and cytostatics allows to achieve stabilization of the process in patients with CSS.
Highlights
Experience in managing patients with Churg-Strauss syndrome
Romuz N.A. Our goal was to analyze the possibilities of improving the diagnostics of Churg-Strauss syndrome (CSS)
improve the effectiveness of treatment according to the existing literature
Summary
Experience in managing patients with Churg-Strauss syndrome. Khanyukov A.A., Lakiza Т.V., Simonova Т.А., Pryazhnikova L.S., Poleshko V.Yu., Romuz N.A. Одним из таких заболеваний является синдром Чарджа-Стросса (СЧС) – это эозинофильное гранулематозное воспаление дыхательных путей с формированием некротизирующего васкулита сосудов мелкого и среднего калибра с бронхиальной астмой и эозинофилией [1, 10]. Однако клинические и патологические признаки заболевания были описаны лишь в 1951 году Jacob Churg и Lotte Strauss [8], СЧС с этого времени называется их именами.
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