Abstract

Even though it is known that the virus of hepatitis A may be transmitted by the parenteral route, 1 we hardly ever think of this possibility when hepatitis follows transfusion of blood or blood products. Almost invariably, we assume that the disease is hepatitis B. Meyers et al 2 remind us that this assumption can be misleading. They have investigated an outbreak of hepatitis in a bone marrow transplant unit. Overt disease developed within a period of three months in nine patients with a marrow transplant and in six donor-members of their families. Subclinical hepatitis, evidenced by increased serum glutamic oxalacetic transaminase concentrations, was detected in 21 additional cases among family members, staff members, and other donors, and 69% of patients receiving platelet transfusion during the period of risk. Unexpectedly, the short incubation period as well as the clinical and serological features of the illness were compatible with hepatitis A

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