Abstract

Laboratory networks were established to provide accurate and timely laboratory confirmation of infections, an essential component of disease surveillance systems. The World Health Organization (WHO) coordinates global laboratory surveillance of vaccine-preventable diseases (VPDs), including polio, measles and rubella, yellow fever, Japanese encephalitis, rotavirus, and invasive bacterial diseases. In addition to providing high-quality laboratory surveillance data to help guide disease control, elimination, and eradication programs, these global networks provide capacity-building and an infrastructure for public health laboratories. There are major challenges with sustaining and expanding the global laboratory surveillance capacity: limited resources and the need for expansion to meet programmatic goals. Here, we describe the WHO-coordinated laboratory networks supporting VPD surveillance and present a plan for the further development of these networks.

Highlights

  • Laboratory-supported surveillance is a critical component for strategies to control, eliminate, and eradicate infectious diseases, including vaccine-preventable diseases (VPDs)

  • System and TB Supranational Reference Laboratory Network were not built on the polio and measles–rubella platforms, and are too complex to describe in this manuscript

  • Following the adoption of a global goal to eradicate polio by the World Health Assembly (WHA) in 1988, the World Health Organization (WHO) developed a global network of laboratories to ensure high-quality laboratory diagnosis of suspect cases of poliomyelitis [2]

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Summary

The Journal of Infectious Diseases SUPPLEMENT ARTICLE

Expansion of Surveillance for Vaccine-preventable Diseases: Building on the Global Polio Laboratory Network and the Global Measles and Rubella Laboratory Network Platforms. The World Health Organization (WHO) coordinates global laboratory surveillance of vaccine-preventable diseases (VPDs), including polio, measles and rubella, yellow fever, Japanese encephalitis, rotavirus, and invasive bacterial diseases. In addition to providing high-quality laboratory surveillance data to help guide disease control, elimination, and eradication programs, these global networks provide capacity-building and an infrastructure for public health laboratories. Measles; rubella; polio; yellow fever; Japanese encephalitis; rotavirus; invasive bacterial disease; laboratory network; surveillance. The World Health Organization (WHO) and Member States coordinate global laboratory networks to support surveillance for selected VPDs, including polio, measles, rubella, yellow fever (YF), Japanese encephalitis (JE), rotavirus, influenza, tuberculosis, and invasive bacterial disease (IBD) [1]. System and TB Supranational Reference Laboratory Network were not built on the polio and measles–rubella platforms, and are too complex to describe in this manuscript

GLOBAL LABORATORY NETWORKS FOR VPD SURVEILLANCE
Measles and Rubella
Number of sequences submitted to the GMRLN databasesd
Yellow Fever
Japanese Encephalitis
Invasive Bacterial Disease
LESSONS LEARNED FROM VPD LABORATORY NETWORKS
Findings
FUTURE OF VPD SURVEILLANCE NETWORKS IN A POSTPOLIO ERADICATION WORLD
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