Abstract
The aim of this study is to investigate the effect of different doses of Velosef in magnesium silica/chitosan nanocomposite in terms of structural, morphology, optical properties, and bioactivity. Loading Velosef in fine-sized magnesium silica/chitosan is an efficient engineering approach for drug delivery. The sol-gel process was used to prepare magnesium silica fine-sized before being blended into chitosan matrix, which acts as a potential morphogenetic biomaterial. The Velosef/magnesium silica/chitosan nanocomposites were characterized by XRD, TEM, SEM, FTIR, UV-absorption, and antimicrobial studies. The XRD was characteristic the crystallinity degree of the MgO-SiO2/chitosan/Velosef nanocomposites with a three maximum peaks at 26.37°, 33.34o, 36.9°. FTIR results indicated the structural change occurred with the Velosef sol-gel polymerization process. UV-absorbance reveals that the MgO-SiO2/chitosan nanocomposite appeared a high performance for loading Velosef at two absorption bands at 253 and 347 nm. The MgO-SiO2/Chitosan/Velosef nanocomposites showed considerable antimicrobial activity in opposition to the tested representative microorganisms. The maximum antimicrobial activity was obtained with MgO-SiO2/Chitosan against both Escherichia coli and Candida albicans (37 mm), while the minimum antimicrobial activity (30 mm) was recorded against B. mycoides and E. coli with control.
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