Abstract
Chromatographic separation techniques are widely applied for complex separations. For binary or pseudo-binary separation problems, it is well known that continuous chromatographic separation proces...
Highlights
In fine chemical and pharmaceutical industries, chromatographic separation techniques are widely used to isolate valuable target components from complex mixtures
The shortcut design method based on the equilibrium theory is often used to assess the process feasibility in the early stage of process design
According to the shortdesign methods of the double-layer simulated moving bed (SMB) and two alternative ternary SMBs, these SMB processes were compared with respect to productivity and desorbent consumption
Summary
In fine chemical and pharmaceutical industries, chromatographic separation techniques are widely used to isolate valuable target components from complex mixtures. The simulated moving bed (SMB) technology was introduced and developed as one of the most promising continuous separation in liquid− solid chromatography for the separation of binary and pseudobinary.[1] The conventional four-zone SMB forms a closed ring with several packed columns. This ring is divided into four zones by two inlets (feed and desorbent) and two outlets (extract and raffinate). The true counter-current separation processes such as fractional distillation reach the steady state, the SMB process does not reach the steady state but the cyclic steady state (CSS) because of the periodic repetition of port switching
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