Abstract
Hyperbranched polyglycerols (HPG) were covalently grown from hydroxyapatite nanocrystals (HAP NCs) via surface-initiated anionic ring-opening multibranching polymerization (SI-AROMP) of glycidol. HAP NCs were first functionalized by (3-mercaptopropyl)-trimethoxysilane to get HAP-SH NCs. Then, SI-AROMP of glycidol was accomplished to afford HPG grafted HAP NCs (HPG-g-HAP). The structure and morphology, and charge behavior of HPG-g-HAP nanocomposites were investigated by FT-IR, TGA, TEM, SEM, XRD, and zeta potential measurements. A model drug ibuprofen (IBU) was employed to evaluate the drug loading/release behavior of the HPG-g-HAP nanocomposites. In vitro IBU release profile suggested the nanocomposites as a promising drug delivery system (DDS).
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