Abstract
Expanded-spectrum β-Lactamase and Plasmid-mediated Quinolone Resistance
Highlights
Amplicons were confirmed by DNA sequencing and used as probes in hybridization experiments on purified plasmids
These results indicated that the genes encoding QnrA1 and VEB-1, when identified concomitantly in a given isolate, were always located on plasmids belonging to the same IncA/C -incompatibility group 2 that may vary in size and digestion pattern (Table; unpub. data)
It is remarkable that since VEB-1 is apparently always encoded by IncA/C plasmids, when 2 genes for QnrA1 and VEB-1 are found together, they occur on IncA/C2 plasmids
Summary
Amplicons were confirmed by DNA sequencing and used as probes in hybridization experiments on purified plasmids (data not shown). *Ref., reference; ESBL, expanded-spectrum β-lactamase; NAL, nalidixic acid; K, kanamycin; SSS, sulfonamides; C, chloramphenicol; RA, rifampin; TM, tobramycin; SXT, trimethoprim-sulfamethoxazole; TE, tetracycline; ND, not determinable; NA, not applicable. BlaVEB-1-positive plasmids (including 11 qnrA1-positive) belonged to the
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