Expanded Mobius Syndrome

J Gordon Millichap

doi:10.15844/pedneurbriefs-15-6-9

Abstract

An infant born with Mobius syndrome died at 22 days and was found at autopsy to have more widespread involvement of brainstem and cranial nerve nuclei than usual, resulting in an “expanded Mobius syndrome,” as reported from the University of Iowa Hospital, Iowa City, IA.

Highlights

The predictive value of presenting symptoms, MRI and CT findings, and etiology in the outcome of ischemic arterial childhood stroke was determined in a consecutive series of 31 patients followed at the University Hospital, Rotterdam, The Netherlands
An infant born with Mobius syndrome djed at 22 days and was found at autopsy to have more widespread involvement of brainstem and cranial nerve nuclei than usual, resulting in an "expanded Mobius syndrome," as reported from the University of Iowa Hospital, Iowa City, IA
Mobius syndrome is a congenital disorder usually limited to a bilateral paralysis of cranial nerves VI and VII, resulting in facial diplegia and impaired abduction of the eyes in lateral gaze

Summary

PROGNOSTIC FACTORS IN ISCHEMIC ARTERIAL STROKE

The predictive value of presenting symptoms, MRI and CT findings, and etiology in the outcome of ischemic arterial childhood stroke was determined in a consecutive series of 31 patients followed at the University Hospital, Rotterdam, The Netherlands. Hemiparesis was the most common presenting symptom (74%), seizures occurred in 19%)altered level of consciousness in 16%)and ataxia in 7%. Risk factors at presentation that correlated with a poor prognosis were an altered level of consciousness, seizures, and a completed stroke of the MCA. Prognostic indicators of outcome in ischemic childhood stroke. (Respond: Dr Catsman-Berrevoets, Child Neurologist, Dept of Child Neurology, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands). The early risk factors for this poor outcome were an altered level of consciousness at presentation, seizures, and MRI evidence of complete or end-zone MCA infarction

EXPANDED MOBIUS SYNDROME

MOBIUS SYNDROME AND AUTISTIC SPECTRUM DISORDER

Findings

JUVENILE DERMATOMYOSITIS WITH GENERALIZED EDEMA