Abstract
Purpose: Meniscus tears and defects alter biomechanical function and accelerate osteoarthritis (OA) progression. The orthopedic community has emphasized the importance of “saving the meniscus”. However, this tissue has limited intrinsic regeneration capacity because of the low cellularity of endogenous recruited cells and there is no disease-modifying treatment to regenerate meniscus defects and tears. Hence, novel technologies are required for meniscus regeneration. Exosomes are nano-sized (50-200 nm) membrane vesicles with bioactive lipids, nucleic acids (mRNAs and microRNAs), and proteins, and contribute to the regeneration capacity of mesenchymal stem cells (MSCs).
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