Abstract
Skin aging occurs inevitably as a natural result of physiological changes over time. In particular, solar exposure of the skin accounts for up to 90% of skin damage. Numerous studies have examined the ability of dietary constituents to prevent skin aging, and recent research has emphasized the role of functional probiotics in intestinal function and skin aging. However, the mechanism of the interactions between aging and probiotics has not been elucidated yet. The aim of this study was to determine the role of exopolysaccharides (EPS) produced by lactic acid bacteria (LAB) identified as Lactobacillus plantarum HY7714 in regulating tight junctions in intestinal epithelial cells and increasing moisture retention in human dermal fibroblasts cells. We observed that HY7714 EPS controlled intestinal tight junctions in Caco-2 cells by upregulating the genes encoding occludin-1 (OCL-1) and zonula occluden-1 (ZO-1). In addition, HY7714 EPS effectively improved UVB-induced cytotoxicity and hydration capacity in HS68 cells by downregulating production of metalloproteinases (MMPs) and reactive oxygen species (ROS). In summary, HY7714 EPS is an effective anti-aging molecule in skin and may have therapeutic potential against skin diseases and UVB-induced damage. Therefore, HY7714 EPS serves as a functional substance in skin–gut axis communication.
Highlights
Skin aging is a complex process caused by both extrinsic and intrinsic factors [1]
To purify and separate the EPS, ethanol precipitation an treatment was performed on the supernatant, yielding 2 g lyophilized EPS per cauclitdubraec.teria HY7714 is granted the status of GRAS and is known to be the suitable candidates for the production of functional EPS and derivative carbohydrates
We found that EPS from L. plantarum HY7714 has the potential to protect against UVB-induced photoaging in human dermal cells, and to regulate tight junctions in human intestinal cells
Summary
Skin aging is a complex process caused by both extrinsic and intrinsic factors [1]. Intrinsic aging is a natural process associated with physiological, hormones, genetic, and cellular metabolic changes [2]. Extrinsic aging is the result of various environmental causes, including air pollution and exposure to sunlight. ROS production caused by exposure to high UV radiation is closely related to oxidative stress in dermal cells [4]. Excessive ROS can indirectly generate DNA changes and membrane imbalances, resulting in a decrease in collagen synthesis. This oxidative stress is responsible for skin aging and disease development [5]. Because skin is the most important and largest surface barrier in the body, it is essential to prevent UV-induced injury in the reconstituted human epidermis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
