Exophytic Tumors on Ankles of a Patient with Psoriasis

Abstract

Diagnosis: Extragenital giant condyloma. Sections of the biopsy specimen obtained from the patient's left ankle (figure 1) showed an acanthotic epidermis with overlying compact hyperparakeratosis and papillary epidermal proliferation (figure 2). Typical cytopathic changes, including enlargement of keratinocytes and perinuclear halos, indicated a human papillomavirus (HPV) infection (figure 3). Further viral typing by nested PCR confirmed the pathogen to be HPV type 11, a commonly encountered mucosal-type HPV. In accordance with previously published methods [1], the general consensus primers MY09 and MY 11 were used in the first PCR to amplify the corresponding HPV LI gene, followed by the second, nested PCR primers GP+5 and GP+6. HPV typing by DNA autosequence was analyzed using the online BLAST server.