Exogenous surfactant in the late respiratory phase of COVID-19

K G Shapovalov,V А Konnov,O А Rozenberg,S А Lukyanov

doi:10.21292/2075-1230-2021-99-5-7-13

Abstract

The article presents data on the course of inhalations with a native surfactant administered in two patients (66 and 53 years old) at the late respiratory phase of the new coronavirus infection of COVID-19 (the 22nd and the 19th days from the disease onset) who received non-invasive artificial lung ventilation.Subjects and methods.For inhalations, an AeroNeb™ micropump nebulizer was used; for one inhalation, 75 mg of surfactant-BL was dissolved in 5 ml of isotonic sodium chloride solution. The treatment course included 5 days with 2 inhalations a day.Results.In both patients, upon the end of this therapy with the native surfactant, regression of respiratory failure was noted, the level of respiratory support was reduced to insufflation with humidified oxygen, and rehabilitation measures were started with subsequent discharge from the hospital.

Highlights

Представлены данные о курсовом ингаляционном введении препарата нативного сурфактанта двум пациентам (66 и 53 лет) в поздней респираторной фазе новой коронавирусной инфекции COVID-19 (22-е и 19-е сут заболевания), находящимся на неинвазивной искусственной вентиляции легких
The article presents data on the course of inhalations with a native surfactant administered in two patients (66 and 53 years old) at the late respiratory phase of the new coronavirus infection of COVID-19 who received non-invasive artificial lung ventilation
Upon the end of this therapy with the native surfactant, regression of respiratory failure was noted, the level of respiratory support was reduced to insufflation with humidified oxygen, and rehabilitation measures were started with subsequent discharge from the hospital

Summary

Introduction

Экзогенный сурфактант в поздней респираторной фазе COVID-19 Представлены данные о курсовом ингаляционном введении препарата нативного сурфактанта двум пациентам (66 и 53 лет) в поздней респираторной фазе новой коронавирусной инфекции COVID-19 (22-е и 19-е сут заболевания), находящимся на неинвазивной искусственной вентиляции легких. А. Экзогенный сурфактант в поздней респираторной фазе COVID-19 // Туберкулёз и болезни лёгких.

Results

Conclusion