Exogenous oxytocin decreases interestrous interval of cyclic gilts.

Abstract

Oxytocin (OT) stimulates pulsatile secretion of uterine PGF2 alpha in ruminants, but the role of OT in regulation of the estrous cycle of pigs is not clear. four experiments were performed to examine the effect of exogenous OT on interestrous interval of intact cyclic and hysterectomized gilts. In Exp. 1, i.v. injections of 20 USP units (equivalent to 20 IU) of OT, once/day via an ear vein on d 10, 12, 14, and 16 after estrus, decreased (P < .01) interestrous interval (19.9 +/- .2 d) compared with vehicle-injected control gilts (20.8 +/- .2 d), without affecting ovulation rate (12.1 vs. 12.0 +/- .7 corpora lutea; OT vs control gilts) at subsequent estrus. In Exp. 2, i.v. infusions of 20 USP units of OT, twice/day via an indwelling jugular catheter on d 10 to 16 after estrus, did not alter interestrous interval (20.6 +/- .3 d) compared with control gilts (20.4 +/- .3 d). Concentrations of progesterone in jugular vein plasma did not differ between treatment groups on d 9 to 21 after estrus. In Exp. 3, i.m. injections of 20 USP units of OT, twice/day on d 10 to 16 after estrus, decreased (P < .05) interestrous interval (20.6 +/- .4 d) compared with control gilts (22.3 +/- .4 d). In Exp. 4, i.m. injections of 20 USP units of OT, twice/day on d 10 to 16 after estrus, decreased (P < .05) interestrous interval (20.7 +/- .3 d) compared with control injections in uterine-intact gilts (21.8 +/- .3 d). None of the gilts hysterectomized on d 7 and treated on d 10 to 16 after estrus with either OT or control injections returned to estrus by d 28, and all had increased plasma progesterone on d 21 to 27. Mean weight of individual corpora lutea (502 vs 449 +/- 28 mg; OT vs control gilts) and total weight of corpora lutea (5,758 vs. 5,126 +/- 298 mg; OT vs control gilts) of hysterectomized gilts did not differ between treatment groups at ovariectomy on d 28. These results indicate that 1) exogenous OT administered on d 10 to 16 shortened the interestrous interval of intact cyclic gilts and 2) the effect of OT was uterine-dependent.