Abstract
Natural glycoproteins can induce apoptosis of tumor cells and exert anti-tumor activity by immunomodulatory functions, cytotoxic and anti-inflammation effects, and inhibition of endothelial growth factor. Given their prospects as novel agents, sources of natural antitumor glycoproteins have attracted attention and new research directions in glycoprotein biology are gradually shifting to the direction of cancer treatment and prevention of neoplastic disease. In this review, we summarize the latest findings with regard to the tumor suppressor signature of glycoproteins and underlying regulatory mechanisms.
Highlights
Glycoprotein for protein and sugar chain of covalent compounds, the glycoprotein in sort is more, widely distributed in animals, plants, and microorganisms, with free or combined with state widely exists in the cells inside and outside
A 150kDa glycoprotein was isolated from Solanum nigrum can effectively inhibit the activity of human HCT-116 colon cancer cells and human breast cancer MCF-7 cells, and its mechanism may be used a dose-dependent inhibition of protein kinase PKC-α, regulating nuclear factor NF-κB DNA binding activity, stimulation of intracellular NO production, suggesting that the plant Solanum glycoproteins can induce tumor cell apoptosis through regulatory mechanisms of cell signaling medium (Lee et al, 2004; Heo et al, 2005)
Sichuan pepper isolated from Zanthoxylum was 24kDa glycoprotein has antioxidant and anti-cancer effects, through the study of Balb/c mice hepatoma cells showed that the anti-tumor effect by increasing the Balb/c mice body piercing hormone secretory activity and granzyme B and NK cells, inducing the expression of cytochrome C-related factors hepatocellular apoptosis and caspase-3, to promote apoptosis of tumor cells play a role in tumor suppression (Lee et al, 2014)
Summary
Glycoprotein for protein and sugar chain of covalent compounds, the glycoprotein in sort is more, widely distributed in animals, plants, and microorganisms, with free or combined with state widely exists in the cells inside and outside. Natural glycoproteins can induce apoptosis of tumor cells and exert anti-tumor activity by immunomodulatory functions, cytotoxic and anti-inflammation effects, and inhibition of endothelial growth factor.
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