Exogenous iron redistribution between brain and liver after administering 57Fe3O4 ferrofluid to a rat brain ventricle

Abstract

The natural excretion of 57Fe enriched magnetic nanoparticles from a rat’s brain through its blood–brain barrier is studied. Dextran-coated iron oxide nanoparticles are transcranially injected into the rat’s brain ventricle. The injected nanoparticles undergo biotransformation into iron-containing proteins distributed over the brain tissues, while the exogenous iron transported from the brain to other organs is eliminated from the body over time.